Prognostic value and association of systemic inflammation for patients with stage IV gastric cancer
| Journal | Volume 83 - 2020 |
| Issue | Fasc.2 - Original articles |
| Author(s) | C. Huang 1, Z. Li 2, Z. Zhang 1, X. Xia 1, D. Xu 1, A. Zhao 2, G. Zhao 1 |
| Full article |
 PAGES 255-263 VIEW FREE PDF |
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Affiliations: (1) Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
(2) Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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Objective: The present study is aimed at investigating the prognostic value and association of systemic inflammation (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and lymphocyte-to-monocytes ratio) for patients with stage IV gastric cancer. Methods: In this retrospective study, patients with stage IV gastric cancer between January 2008 and December 2017 were included. A summary was performed on clinicopathological characteristics and a multivariate cox regression analysis was performed to identify the prognostic factors. Results: 304 patients with stage IV gastric cancer were included in the study. On multivariate analysis, the systemic chemotherapy (p < .001), the jaundice (p = .004), the high neutrophil-to-lym- phocyte ratio (p = .005) and the high platelet-to-lymphocyte ratio (p = .041) were independent prognostic factors for patients with stage IV gastric cancer. Conclusion: As systemic inflammation response markers, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are significantly associated with OS for stage IV gastric cancer patients. Systemic chemotherapy shows a clear overall survival benefit in patients with stage IV gastric cancer and Jaundice indicates poor overall survival. Keywords: stage IV gastric cancer, systemic inflammatory response. |
| The authors declare that they have no conflict of interest. |
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© Acta Gastro-Enterologica Belgica. PMID 32603044 |
